I'm starting to find that going into floors 400+, it doesn't matter how much hp/dodge I have, because I get oneshot anyways.
I'm currently using an equivalence+balance+harmony build with my defiant orb+adventurer+momentum set (with hp/mp leech on two crystal affixes and dodge on two more), but I'm still dying a lot more than I'd like.
How do people stay alive on high floors?
I've noticed some builds ignore defence altogether and go straight for CC effects + pure damage. Does that work, and if I do that how do I deal with projectiles?