This is my thought process at the moment. 'Plagued' is on my necklace at the moment. At some point, I'm hoping to get the choker, but then I'll, be missing 'plagued'. I had this as a drop a while ago:
Giving me plagued, but then I'll be missing out on explosion as you mention. The issue with the item is that it has the set(4) bonus from plagued, which I'll be missing out on - Unless I implement this in my build:
But who knows, maybe something else will drop before I even reach that point:p It's the beauty of this game imo!