@Short when I got up to those levels, Dodge 60% really helped out. as long as you can kill or immobilize the monsters before they can attack you, the few that do are easier to Dodge than if you are Dodging 10+ attacks at once. now I have 60% Dodge and 45% Block, and it is working nicely. I have Sanctuary and Dodge 20% on the Hireling gear that I am using for Ascending my Hirelings. the Hireling doesn't die that much, and the Sanctuary keeps the number of deaths down.
basically you need a build that is good at killing monsters fast, so you don't die very often, or enough Dodge, Block, Sanctuary combinations to keep you alive long enough to kill the monsters before they take your weapons for trophies. the higher you go up in floors, the better the monsters are at killing you with one hit. if you want, go to a lower difficulty level so that you don't die as much, so you can get a feel for a build that can survive the higher floors, and then go back to M3.