if you are climbing for items and loot, just focus on survival and attack affixes/sets. later, you can make gear that can also farm. check out the forums for Main/Hireling Climbing and/or Farming Combinations. I just went from an Ascending Build to a Farming Build, and as I was tweaking the Farming Build, it was able to climb higher and higher. I am up around Floor 880's with my Farmer, but I took a break to work on getting one of my Character Slots turned into a PVP Toon. when I get up to Floor 1k, that is as far as I want to take my Farmer. that is when I will work on making a Climbing Build to go even higher.