it would be useless if you do so. best thing you can do is add crystal affix
I would remove the Deadly Strike epic affix with a Kyanite, and then use a Diamond to reroll the Poison DMG % until it’s 100. Then I would use an Obsidian to add a crystal affix. Maybe attack speed or critical damage, it really depends on what else you’ve got in your build. But then you’d still have an empty socket afterwards, to put in a mythstone or remove it and add a legendary affix.