Or... you can specialize your farming, pending on what it is you wish to farm for.
For eg: a lot of people are really only interested in obtaining a lot of CS. So if you want to optimize CS farming, forget about luck gold find etc. Focus everything into Item Drops... 350%+ and crystalline for increased tier rarity., then the the rest into survive / dps... then crank dat floor level up to 500
It really depends on what your target farm is. I prefer specialized farm builds, but hybrids can work out ok too.
PS : I also personally enjoy giant pick up radius on my CS farmer. Picking up just off screen.
TBH I'm not even sure if crystalline tier rarity stacks with floor tier rarity, but this method gets me all the CS I desire