the higher you go up the Floors, the more monsters that can 1 hit you. eventually, you need to replace +HP, AR, and Resist with Dodge, Block, Sanctuary, and Movement Speed. on top of that, you need to be able to kill the monsters fast, or be able to move around a lot while killing the monsters. I haven't really used Sanctuary, except on my Ascending gear for my Hireling, and Dodge 60% lasted me a long time, with learning how to kill monsters fast. I recently started adding Block 45% to my builds, and it helps a lot. but no matter how much defense you have, if the monsters pile up faster than you can kill them, they will overwhelm your defense with greater numbers. so either lots of damage, or lots of mobility, or both, to help any defense you have. at the moment, I am running a Farm Wizard to Ascend my PVP Wizard as a Hireling. my Farm Wizard is up to Floor 880ish in M3 with a Crushing Flames based build, but I put climbing floors on hold for awhile to Ascend my other Character slots.