Defense: with only Dodge +60%, you might want to add Sanctuary Mythic to your Amulet. it has a 30 second cool down until it will save your life again, but it’s still a good thing to have. also, using Orb OH Weapon with Teleport to move around and out of danger is very helpful (I used this a lot in my Noob days) or increased Movement Speed. or put a Crystal +45% Block on your OH. I have a few builds with +60% Dodge & +45% Block, and sometimes Sanctuary, works great.
Crushing Flames/Blow: it’s 25% of current enemy HP. for each Tier higher of monster, CB takes a lower amount of the enemies current HP. 25% for Normal Tier, 25% x 25% = 6.25% (0.25 x 0.25 = 0.0625) for Magic Tier, 25% x 25% x 25% for Rare Tier, and so on. you might want to change one of your Set’s to Demonic, or find an Item with Legend Execute +100%. these increase damage done when you get enemy HP to 25% or lower.
this looks like a Farm Build, so you don’t really need to use it on floors higher than 500-510, unless you need to farm for Item on floors higher than 500 up to 1000.
stick to Reactor, and use Legend Blistering on a few Items. also add Epic +50% Bleed Damage. you will need Legend Elemental Crit +30% (1 or 2) or 2-3 Immolate. if you are using Wizardry Talent, you wont need either of these. Sorcery 20 (+100% to your Fire DoT damage), Wizardry 20 (20% Immolate), Magnify 20 (increase AoE of your Orb Skill, and increase range of Reactor), and Fester 20 (Fire DoT lasts 50% longer and is 50% faster).
do you have Epic +100% Weapon Damage (Legend +200% Weapon Damage would be better) on your MH and at least one Epic +20% Elemental (Fire) Damage on your Equipment (one Legend +100% Elemental (Fire) damage would be better)? this would be a great boost to damage.
are you using Orb with Reactor to do most of your damage? make sure you get your Cool Down to +45% to +60%. you’ll see a huge improvement in damage with the Reactors, because you will be casting Orb faster. if you can put a Legend Explosion +400% on one of your Items, that will really make your Reactor and Fire DoT’s better damage dealers with a 5% chance to do an AoE explosion.
it’s tough giving a Farm Build killing power, as you need space for the farming affixes.