I’d choose a reasonable goal to start off with. Perhaps getting your first ascension is a great place to start! Long term goals like reaching floor 2000 or reaching Eternal League can be pretty motivating as well.
Here’s a pretty great intro/tips guide by @Skaul Skaul’s Hierarchy of Tips and Tricks [SHTT] [2.5]
If getting to Eternal League sounds interesting, here’s a great youtube series by @Griffin012: https://www.youtube.com/watch?v=s4neNvpYSL0