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Map Affix Heal +1% to +5%. This allows ALL enemies on the Map to Regenerate the indicated % of their total/maximum HP every second. on higher floors, it would be possible for enemies, especially Epic+ monsters, to Regenerate faster than your Damage Per Second.
Your choices are to make a Character that does even more Damage/DPS or use the Larimar Crystal to change the affixes on the Map before you enter it so that it does not have Heal on it.
Monster Affix Greatly Resist. this reduces the damage of one Element by -75% or x 0.25. there are 5 Elements, so there are 5 different Greatly Resist.
1000 Fire DMG x 0.25 Greatly Resist Fire = 250 Fire DMG.
Map Element Resist. all monsters on a Map are -50% or x 0.5 resistant to the Maps Element. there are 4 Map Elements: Poison, Shock, Ice, Fire.
1000 Fire DMG x 0.5 Map Fire Resist = 500 Fire DMG.
if a monster on a Fire Map has Greatly Resist Fire, the Resists stack multiplicatively.
1000 x (0.5 x 0.25) =
1000 x 0.125 = 125 Fire DMG.
there is also a Map Affix that increases the Element Resists of all monsters on a Map, so you do even less Damage.
Ignore Resist - a Legend Affix that can be rolled with Ruby or found on some Items. your damage is not reduced by enemy resists or immune.
Arcane Element. there are no Arcane Element Maps, there are no enemies resistant or immune to Arcane Element. some monsters may randomly Greatly Resist Arcane Element.
Weaken Affix. a % chance to do Weaken DMG. the cap is 200, so Weaken +100% or higher does Weaken DMG on all attacks.
1000 Fire DMG x ((0.5 Fire Resist x 0.25 Greatly Resist Fire) + (30% Weaken)) =
1000 x ((0.5 x 0.25) + (0.3)) =
1000 x (0.125 + 0.3) =
1000 x 0.425 = 425 Fire DMG. 30% of Fire attacks do 425 DMG while 70% of Fire attacks do 125 Fire DMG. as you can see, the more Weaken you have, the more DMG you do and better DPS.
Fire - Ice oppose each other
Poison - Shock oppose each other
Elements that oppose each other do +25% Effective DMG or x 1.25 Effective DMG. this is affected by Greatly Resist. A monster on a Fire Map might have Greatly Resist Ice.
10k Ice DMG x (0.25 Greatly Resist Ice x 1.25 Effective Ice DMG) =
10k x (0.25 x 1.25) =
10k x 0.3125 = 3125 Ice DMG. with +30% Weaken, 30% of your Ice attacks would do 6125 DMG.
do not forget Critical DMG, which can get up to 5x Critical DMG. Deadly Strike is a % chance to double Critical DMG.
Ignore Resist only takes one space, but does not do Effective DMG.
Weaken lets you do Effective DMG but takes up 2 or more spaces when higher than +90% (Crystal Weaken +90% is one space, Crystal Weaken & 1 Epic +30% Weaken is +120% Weaken but takes up 2 spaces)