This is my personal guide that I follow. Fairly easy and it’s been pretty good to me.
Once you reach floor 200. Stick to that floor. This is what I do.
I put it on Very Easy(just 1 shots the entire time) so farming is super easy. I clear the entire map and then kill the boss at the end. I repeat for a few hours. I usually come out of my farming with 30-40 legendaries(convert these into crystals) sometimes an eternal legendary, and almost always a Nadroji or pretty rare piece and usually around 2-3 million gold. My gear is Just all +5 fortune and pickup radius gear. With a Crystalline helm/Weapon and +Luck Ring/Neck. All found doing this. Anyone can do this, once you get super awesome gear, you can start progressing up the map levels.
This is what I found on my last run.