Pretty much. All of the game-changing items drop more often there. Just stack up Luck, Item Drop, and Gold Find, and use the Crystalline, Nadroji, and Eternalized set affixes. Make sure you convert eternal and crystal legends with no use (or foreseeable use) so you can obtain many ultra rare crystals, and look here for a guide on crystals:
Make sure to play on a difficulty where you’re not spending lots of time dying and where you can quickly wipe the map (at a speed comfortable for you). And, if you have a hireling: USE IT. They give an automatic 100% increase to Item Drop.