Which One Is The Best In Pve In Fighting High Resistant Monsters?

[NUIQUE]

Mid's - Weaken vs. Effective vs. Ignore Resist - Guide [3.0]

Contents Introduction The Enemy Resistance System (PvE) 2.1 Base Resistance 2.2 Resist, Greatly Resist and Immune Affixes 2.3 Enemy’s Usual Weakness 2.4 Examples Weaken Effective (Mythic) Ignore Resist Analysis and Comparison 6.1 Crystal Weaken (compared to Ignore Resist) 6.2 Effective (compared to Weaken and Ignore Resist) 6.3 Arcane Damage Conclusion (the TLDR Part) 1. Introduction It’s been some time now that I’ve been wondering how Ignore Resist, Weaken and Effective work exactly.…

Midlumer did a great job on this.

Short answer:
1st. Weaken
2nd. Effective Mythic
3rd. Ignore Resist