Interesting build but try 100% ED where possible instead of 20% poison dmg. 200% WD on your main weapon, use a different resource Mythic such as “Energy” . or Fury with the primary weapon. If not 200% WD, add epic 100% weapon dmg on Wand if you don’t want to change weapon.
Add crystal affixes such as 225% crit , potentially 90% weaken later if not ignore resist, crystal 45% crit chance. If not use epic 75% crit for now. Crystal Luck or gold if farming. Crushing blow 30% , deadly strike if you crit damage.
Legend 50% Item drops to save slots from fortune mythstone later. There, you slowly build a budget farm or floor build into a high end one with time .
Can confirm plagued still good, easy floor 1000 farm clears thanks to it. Crushing flames or frozen builds are also options but stick with plagued.
Other affixes you can do are 100% execute dmg or demonic which both go well with Plagued. Fester talent is like Inferno for Poison + extra duration. Add another Blight if you want.
Double Strike is another option, Glasscannon, Barbarian/Push the Limit.
Keep 30% elemental crit instead of adding Aethereal Drain set. Keep Equality as well or as a resource Mythic, use Equality+ Equivalence Mythic combo. + regen with Druidic set. Used to be Equivalence buffed regen quite a bit.
If you go closeup, Earthquake mythics good, but you can always change it.
Talents: keep Fester 20, Magnify, Sorcery. Change wizardy to Amplify since you have Elemental crit already.
Hero points: looks good. Dexterity, your skills, fortune, etc.