I began this game five or six months ago and for the last couple I have been experimenting with this build. In conclusion, it is affective in both PVP and PVE games. I have 3 characters slowly working their way through the PVP leagues under the names of Apocalpyse Saourise, Apocalypse Brandon and Apocalypse Lucas (No points for the originality there !)
The basic skeleton of this build is that each character class has a main hand weapon with the Apocalypse mythic imbued (Hero,Protest,Endow and Quest.). This produces 3 Furies to fight along side of you with a 100% guarantee (unlike a proc affix which is just a chance). As they are summoned at the same time the attack skill is used it could be seen as an extra skill.