there are four basic Builds.
Farm Builds for farming Loot. Luck and Gold Find are a must. Item Drop is important if you want lots more Loot to drop. other Farm Affixes are for Farm Builds that are focused on farming for certain kinds of Loot. of course, killing monsters and surviving is important also! usually only needs to survive up to floor 500, 1000 if you really need an item from these floors.
Ascending Builds are for getting lots of Experience fast, especially for Players who want to get Perks. if you are going to get all 6 Perks, then you want to have +200% Experience on your Ascending Build. killing monsters and surviving is also important. you only need to kill monsters on floors 100 to 200 for experience, as experience from monsters stops going up at floor 100. you should only go to the higher floors if you need a certain item to improve your Build.
Climbing Builds are for going to higher Floors. they just need to do lots of DMG and survive to get to the next higher Floor. you can Climb lower Floors with the Farm & Ascending Builds, but if you are going past floor 1000, getting Experience & Farming will just slow you down if your Build isn’t good enough.
PVP Builds are for Players who want to fight other Players Characters in the Battle Arena.
even if you know a good build, you will still end up spending resources. all players have spent hundreds if not thousands of resources, even if they are making a Build found in the Forums that you know is really good. it is because most Crystals give random results that it requires so much resources, unless you are really lucky, which happens sometimes.
besides, better to make mistakes now while you are still learning than later when it will be very frustrating.